TY  - JOUR
T1  - Preliminary Association Study of SNPs in <I>MFN2</I> Gene Showing Marbling-Associated Expression Changes
AU - Yamada, Takahisa AU - Tong, Bin AU - Muramatsu, Youji AU - Yamamoto, Takuji AU - Tanomura, Hideki AU - Ohta, Takeshi AU - Kose, Hiroyuki AU - Sugiyama, Toshie 
JO  - Journal of Animal and Veterinary Advances
VL  - 11
IS  - 15
SP  - 2796
EP  - 2800
PY  - 2012
DA  - 2001/08/19
SN  - 1680-5593
DO  - javaa.2012.2796.2800
UR  - https://makhillpublications.co/view-article.php?doi=javaa.2012.2796.2800
KW  - Allelic distribution
KW  -MFN2
KW  -close marker
KW  -marbling
KW  -single nucleotide polymorphism
KW  -Japan
AB  - Researchers have previously showed that the <I>mitofusin 2</I> (<I>MFN2</I>) gene involved in energy balance through mitochondrial fusion and expressed in slow-twitch oxidative fiber that is observed in high-marbled muscle, possesses expression differences in musculus longissimus muscle between low-marbled Holstein and high-marbled Japanese Black steer groups. In the present study, researchers found that a marker (IDVGA-49) close to the MFN2 was polymorphic between low-marbled Holstein and high-marbled Japanese Black steer groups and exhibited significantly different allelic distribution between Japanese Black sires with extremely high predicted breeding value for marbling and with extremely low one. Further, researchers detected Single Nucleotide Polymorphism (SNP) in the <I>MFN2</I> gene between low-marbled Holstein and high-marbled Japanese Black steer groups. The allelic distributions of the 6 SNPs in the MFN2 were indistinguishable between Japanese Black sires with extremely high predicted breeding value for marbling and with extremely low one. The findings suggest that an unidentified true causal mutation which is in linkage disequilibrium with the IDVGA-49 marker but not the 6 SNPs may be related to changes in <I>MFN2</I> gene expression and/or marbling. The IDVGA-49 marker may be useful for effective marker-assisted selection to increase the levels of marbling.
ER  -