TY  - JOUR
T1  - Acetamiprid Residues in Male Mice and its Effect on Liver Function
AU - Wang, Xian-Zhong AU - Wang, Yi- AU - Zhang, Jiao-Jiao AU - Xiang, Hai-Yang AU - Hua, Jia- AU - , Zhang 
JO  - Journal of Animal and Veterinary Advances
VL  - 11
IS  - 15
SP  - 2706
EP  - 2710
PY  - 2012
DA  - 2001/08/19
SN  - 1680-5593
DO  - javaa.2012.2706.2710
UR  - https://makhillpublications.co/view-article.php?doi=javaa.2012.2706.2710
KW  - Acetamiprid
KW  -mice
KW  -liver
KW  -residues
KW  -liver function
KW  -impairment
AB  - This study was performed to identify whether acetamiprid could 
  residue in liver and kidney and its effect on liver function. Fifty adult Kunming 
  male mice weighting 25-30 g were randomly grouped and ten mice in each group 
  (five groups: control, blank, acetamiprid alone, acetamiprid+vitamin E, vitamin 
  E alone); all groups were administered for 35 days by intragastric gavage. The 
  residue in the tissues had been detected by the Liquid Chromatography coupled 
  with tandem Mass Spectrometry (LC-MS/MS) and the serum biochemistry parameters 
  were analyzed by an automatic chemistry analyzer. Acetamiprid induced a wide 
  range of nervous signs in mice; the concentration of acetamiprid in liver was 
  higher than that of kidney p<0.05. Furthermore, acetamiprid increased the 
  activity of Alanine Transaminase (ALT), Aspartate Aminotransferase (AST), Alkaline 
  Phosphatase (ALP) (p<0.05 for all) but reduced the activity of Total Protein 
  (TP) and Albumin (ALB) (p<0.05, for both). However, Vitamin E ameliorated 
  the effects of acetamiprid on these parameters, compared to the acetamiprid 
  only group (p<0.05). The results indicated that the liver was the main organ 
  of acetamiprid residues and acetamiprid could affect liver function but VE could 
  reduce acetamiprid-induced impairment.
ER  -