TY  - JOUR
T1  - Anti-Fibrotic Effects of Ganoderma Lucidum and Praziquantel on Liver Fibrosis 
  of <I>Schistosoma japonicum</I>
AU - Xu, Huijuan AU - Zhu, Yangquan AU - Shuai, Lianyun 
JO  - Journal of Animal and Veterinary Advances
VL  - 11
IS  - 13
SP  - 2342
EP  - 2346
PY  - 2012
DA  - 2001/08/19
SN  - 1680-5593
DO  - javaa.2012.2342.2346
UR  - https://makhillpublications.co/view-article.php?doi=javaa.2012.2342.2346
KW  - Schistosoma japonicum
KW  -praziquantel
KW  -ganoderma lucidum
KW  -fibrosis
KW  -anti-oxidation
AB  - Liver fibrosis is the main damage of <I>Schistosoma japonicum</I> (<I>S. japonicum</I>) in chronic and advanced stages. Praziquantel (PZQ) is currently used for all forms of schistosomiasis. Ganoderma Lucidum (GL) as a traditional chinese medicine has been used in many fields such as anti-oxidation, anti-tumorigenesis, immunoloregulation and anti-fibrosis. But the therapy of GL on schistosomiasis and its mechanism were not well revealed. To investigate the anti-fibrotic effects of GL and/or PZQ on <I>S. japonicum</I>-induced liver fibrosis, 60 Kunming mice were infected with <I>S. japonicum</I> repeatedly and treated with Normal Saline (NS), GL, PZQ, GL combined with PZQ, respectively. The results showed that GL treatment could relieve liver injury by decreasing serum Hyaluronic Acid (HA) and Laminin (LN) level and reducing spleen index ameliorating liver injury of infected mice. Researcher also found that the collagen 3 mRNA and TGF-a1 mRNA expression decreased in the mice of GL group and GL combined with PZQ could obtain much better results. Overall the findings revealed that GL can relieve liver fibrosis of <I>S. japonicum</I>especially when combined with PZQ.
ER  -