TY  - JOUR
T1  - Effects of <I>Hypericum perforatum</I> (St. John&#146;s wort) Extract on Renal Ischemic Reperfusion Injury in Rats
AU - Akbar Abolfathi, Ali AU - Doustar, Yousef AU - Mortazavi, Pejman AU - Rezai, Ali 
JO  - Journal of Animal and Veterinary Advances
VL  - 10
IS  - 24
SP  - 3244
EP  - 3248
PY  - 2011
DA  - 2001/08/19
SN  - 1680-5593
DO  - javaa.2011.3244.3248
UR  - https://makhillpublications.co/view-article.php?doi=javaa.2011.3244.3248
KW  - Renal Ischemia/Reperfusion (IR)
KW  -Hypericum perforatum
KW  -acute renal failure
KW  -tissue
KW  -Iran
AB  - Ischemia/Reperfusion (IR) induces severe tissue injury mainly caused by oxidative stress. A considerable body of recent evidence suggests that oxidative stress and exaggerated production of reactive oxidant species play a major role in several aspects ischemia and reperfusion. <I>Hypericum perforatum</I> is a medicinal plant species containing many polyphenolic compounds namely flavonoids and phenolic acids. Because polyphenolic compounds have high antioxidant potential in this study we evaluated the effect of H. perforatum extract on renal ischemic reperfusion injury. Renal ischemic reperfusion was induced in rats by clamping the renal artery for 60 min. After 7 days of reperfusion. <I>H. perforatum</I> extract treatment markedly reduced renal ischemia reperfusion injury in I/R+HP 30 mg kg<SUP>-1</SUP> group comparative with other treatment and sham groups.
ER  -