TY  - JOUR
T1  - Experimentally Induced Toxicity of Ochratoxin A and Endosulfan in Male Wistar Rats: A Hormonal Disorder
AU - Patil, Rajendra Damu AU - Afroz, Masarrat AU - Jain, Arun Kumar AU - Singh, Karan Pal AU - Kumar, Shashi Nandar AU - Telang, Avinash Gopal 
JO  - Journal of Animal and Veterinary Advances
VL  - 10
IS  - 13
SP  - 1750
EP  - 1755
PY  - 2011
DA  - 2001/08/19
SN  - 1680-5593
DO  - javaa.2011.1750.1755
UR  - https://makhillpublications.co/view-article.php?doi=javaa.2011.1750.1755
KW  - hormone
KW  -male rats
KW  -endosulfan
KW  -Ochratoxin A
KW  -radioimmuno assay
KW  -India
AB  - Dietary exposures to food contaminants such as mycotoxin (s) or pesticide (s) are most significant due to their adverse effect on the production and reproduction in animals and human population. The present investigation was conducted to evaluate the adverse effects of Ochratoxin A (OTA) and endosulfan on the male hormonal status. OTA (4 mg kg<SUP>-1</SUP> feed) and endosulfan (5 mg kg<SUP>-1</SUP> body weight) were administered orally alone and in combination for 30 days caused significant alterations on the serum levels of various body hormones such as thyroid hormones (triiodothyronine and thyroxin), testosterone, prolactin, insulin and cortisol of adult male Wistar rats. Radioimmuno assay revealed significantly higher serum levels of Thyroxin (T<SUB>4</SUB>) and prolactin and the significantly lower serum levels of Triiodothyronine (T<SUB>3</SUB>), testosterone, insulin and cortisol in all the treated groups in comparison to control. Moreover, the hormonal changes were maximum in the combination group. In conclusion, the simultaneous exposure of OTA and endosulfan caused more pronounced hormonal alterations possibly may due to their additive interaction in adult male Wistar rats.
ER  -