TY  - JOUR
T1  - Possibilities of Histological Studies in Non-Uremic Rabbit Model of Peritoneal Dialysis
AU - Stojimirovic, Biljana AU - Jovanovic, Natasa AU - Lausevic, Zeljko AU - Krstic, Slobodan AU - Trbojevic-Stankovic, Jasna AU - Trpinac, Dusan AU - Zunic-Bozinovski, Snezana 
JO  - Journal of Animal and Veterinary Advances
VL  - 10
IS  - 11
SP  - 1414
EP  - 1420
PY  - 2011
DA  - 2001/08/19
SN  - 1680-5593
DO  - javaa.2011.1414.1420
UR  - https://makhillpublications.co/view-article.php?doi=javaa.2011.1414.1420
KW  - Peritoneal dialysis
KW  -experimental model
KW  -rabbit
KW  -histological studies
KW  -morphometric analysis
AB  - Investigating peritoneal membrane alterations caused by peritoneal dialysis fluid during peritoneal dialysis in humans is still intriguing but limited. Animal models provide important information about peritoneal changes during long term peritoneal dialysis. The aim of the study was to investigate the possibilities of histological (light and transmission electronic microscopy) and morphometric analyses of peritoneal blood vessels using a modified non-uremic infusion model of peritoneal dialysis on rabbits. The study was done on five adult Chincilla rabbits. A part of infusion system Tro-soluset (Troge Medical GMBH, Germany) was used as peritoneal catheter for daily dialysate instillations. The rabbits tolerated surgical and instillation procedure well, increased body weight and no infection signs nor catheter opstruction were observed during the follow up. Peritoneal tissue samples were obtained during the catheter placement and removal. Morphometric parameters of peritoneal blood vessels (determined with analy SIS 3.1 Soft Imaging System GMbH) showed statistically significant differences before and after peritoneal dialysis. This modified model of peritoneal dialysis on rabbits provided peritoneal tissue samples suitable for histological and morphometric analysis and can be used to study the effects of dialysis solutions on rabbit peritoneal membrane.
ER  -