TY  - JOUR
T1  - Protective Effect of an Inoculum of Lactic Acid Bacteria from Bovine Origin Against <I>Salmonella </I>Serotype Dublin in the Intestinal Tract of Mice
AU - Perdigon, G. AU - Santina, R. Dalla AU - Marti, L.E. AU - Sequeira, G.J. AU - Signorini, M.L. AU - Bertozzi, E. AU - Soto, L.P. AU - Zbrun, M.V. AU - Frizzo, L.S. AU - Rosmini, M.R. 
JO  - Journal of Animal and Veterinary Advances
VL  - 9
IS  - 16
SP  - 2113
EP  - 2122
PY  - 2010
DA  - 2001/08/19
SN  - 1680-5593
DO  - javaa.2010.2113.2122
UR  - https://makhillpublications.co/view-article.php?doi=javaa.2010.2113.2122
KW  - mouse protection
KW  -lactic acid bacteria
KW  -Intestinal tract
KW  -salmonella serotype dublin
KW  -argentina
AB  - The purpose of this study was to determine the capacity of an inoculum of Lactic Acid Bacteria (LAB) of bovine origin-constituted by <I>Lactobacillus casei</I> DSPV 318T, <I>Lactobacillus salivarius</I> DSPV 315T and <I>Pediococcus acidilactici</I> DSPV 006T containing about 10<SUP>9</SUP> cfu dose of each one of the strains to inhibit <I>in vivo </I>the <I>Salmonella </I>serotype Dublin DSPV 595T effects and reduce the pathologic consequences in a conventional group of mice experimentally challenged with a 2.5x10<SUP>5</SUP> cfu dose of the pathogen bacteria. Before the <I>Salmonella </I>serotype Dublin was administered<B>, </B>the treated group (LAB-G = 31 mice) received a 0.1 mL dose of LAB inoculum by daily gavages during 10 days. The control group (C-G = 32 mice) was only inoculated with the pathogen. Individuals weight gain, group food consumption and accumulated morbidity and mortality were daily determined. Each animal health was controlled twice daily throughout all the experiment. The lesions caused by the pathogen were visualized by a hystopathological analysis. The protection of the animals facing the challenge of the used pathogen was demonstrated not only by the highest survival rate of the mice treated with the inoculum versus the control ones but also by the presence of lactic bacteria inoculated mice that did not get ill throughout the experiment. The lactic acid bacteria treatment protected the mice that had been challenged by <I>Salmonella </I>serotype Dublin DSPV 595T. This effect was demonstrated by the higher survival rate of the treated mice when compared to those in the control group.
ER  -