TY  - JOUR
T1  - Partial Protection in Swine Challenged with Porcine Reproductive and Respiratory Syndrome Virus, Vaccinated Against Classical Swine Fever (PAV-250 Vaccine)
AU - , Angel Lozada De Gante AU - , E. Pablo Correa Giron AU - , Aleyda Romero Diaz AU - , Susana Mendoza Elvira AU - , Maria Antonia Coba Ayala AU - , Laura Zapata Salinas AU - , Horacio Lara Puente AU - , Guadalupe Socci Escatel AU - , Jose Galaviz Rodriguez AU - , Xochitl G. Montalvo Aguilar AU - , Abel Ciprian Carrasco 
JO  - Journal of Animal and Veterinary Advances
VL  - 8
IS  - 6
SP  - 1052
EP  - 1062
PY  - 2009
DA  - 2001/08/19
SN  - 1680-5593
DO  - javaa.2009.1052.1062
UR  - https://makhillpublications.co/view-article.php?doi=javaa.2009.1052.1062
KW  - CSF
KW  -vaccination
KW  -PAV-250
KW  -PRRSv
KW  -partial protection
KW  -challenged
AB  - In 2006, a study was carried out to determine whether the attenuated live virus vaccine PAV-250 against Classical Swine Fever (CSF) interacts as a triggering factor in the presentation, pathogenesis and course of the disease caused by the virulent virus of Porcine Reproductive and Respiratory Syndrome (PRRS). Seven Groups (G) were formed and 5 SPF piglets were randomly allocated to each group: G1, negative control; G2, positive control inoculated with PRRSv; G3, vaccinated with PAV-250; G7 and G5, vaccinated with PAV-250 on days-14 and -7, respectively and inoculated with PRRSv on day 0; G8 and G6, inoculated with PRRSv on days -14 and -7, respectively and vaccinated with PAV-250 on day 0. Clinical signs, total white blood cell count by the blood count technique, antibody profile against CSF virus with the ELISA technique and identification of viral nucleic acids by nested RT-PCR were evaluated. Group 6 and 8 showed an increase in clinical signs and groups 5 and 7 did not show apparent clinical signs; body temperature following inoculation increased by 1.5°C on average during 5 days and it subsequently returned to normal (p>0.005). Group 5 and 7 showed post-vaccination leukopenia and post-inoculation leukocytosis and post-vaccination and post-inoculation leukopenia was detected in groups 6 and 8 (p<0.005). In the antibody profile against CSF in groups 5 and 7, antibody rates of 80 and 86%, respectively, were detected; group 6 and 8 had mean antibody rates of 62 and 60%, respectively (p<0.001). When, challenged with CSF virulent Ames strain, these percentages remained constant. Pigs previously vaccinated with the PAV-250 strain did not show clinical and pathological changes when they were infected with the PRRS virus, however, in pigs not vaccinated against CSF and infected with PRRS virus and subsequently with CSF pathogenic virus, the disease worsened, with a 100% mortality rate.
ER  -