TY  - JOUR
T1  - The Effects of Chloramphenicol on Some Biochemical Parameters in Mice
AU - , Hismiogullari Sahver Ege AU - , Kontas Tunay AU - , Hismiogullari Adnan Adil AU - , Essiz Dinc AU - , Eraslan Gokhan 
JO  - Journal of Animal and Veterinary Advances
VL  - 7
IS  - 12
SP  - 1579
EP  - 1582
PY  - 2008
DA  - 2001/08/19
SN  - 1680-5593
DO  - javaa.2008.1579.1582
UR  - https://makhillpublications.co/view-article.php?doi=javaa.2008.1579.1582
KW  - Chloramphenicol
KW  -biochemical parameters
KW  -antibiotic
KW  -hepatotoxity
KW  -mice
AB  - The aim of the study was to investigate the effects of some dose regimens of chloramphenicol on some biochemical parameters in mice for acute and subacute periods. Chloramphenicol was given to the experimental  groups  at  the  doses  of  100  mg  kg <SUP>1</SUP> bw  (group  2)  and  200  mg  kg <SUP>1</SUP>  bw  (group  3) in drinking  water  for  7  days. Blood samples were taken from all animals on day 0, 1, 7 and 14 of the study. The hepatotoxic effect of cloramphenicol occurred in groups 2 and 3 with increasing doses of cloramphenicol. Hepatotoxicity  in groups 2 and 3 was determined based on the levels of increased activity of ALP, AST and ALT.
ER  -