@article{MAKHILLJAVA20151444469,
    title = {Dose-Dependent Isoflurane-Sparing Effect of Maropitant in Dogs Undergoing Ovariohysterectomy},
    journal = {Journal of Animal and Veterinary Advances},
    volume = {14},
    number = {4},
    pages = {95-99},
    year = {2015},
    issn = {1680-5593},
    doi = {javaa.2015.95.99},
    url = {https://makhillpublications.co/view-article.php?issn=1680-5593&doi=javaa.2015.95.99},
    author = {Kazuya,Kimiyoshi and},
    keywords = {Dog isoflurane-sparing effect,maropitant,ovariohysterectomy,morphine,group},
    abstract = {The dose-dependent isoflurane-sparing effect of maropitant in dogs undergoing Ovariohysterectomy (OHE) was investigated. Thirty six female dogs undergoing OHE were randomly divided into 3 groups. The MAR-1 group dogs were premedicated with 1 mg kg<SUP>-1</SUP> maropitant and 0.5 mg kg<SUP>-1</SUP> morphine (n = 12). The MAR-5 group dogs were premedicated with 5 mg kg<SUP>-1</SUP> maropitant and 0.5 mg kg<SUP>-1</SUP> morphine (n = 12). The MOR group dogs received saline and 0.5 mg kg<SUP>-1</SUP> morphine (n = 12). The intraoperative isoflurane-sparing effect was compared among the groups. The mean intraoperative isoflurane requirements during the surgery were 1.88&plusmn;0.10, 1.76&plusmn;0.13 and 1.69&plusmn;0.16% in the MOR, MAR-1 and MAR-5 groups, respectively. The requirements of the MAR-1 and MAR-5 groups were significantly lower than that of the MOR group. The mean intraoperative isoflurane requirement during the surgery of the MAR-5 group was the lowest of all 3 groups. The isoflurane requirement at 40 min after the start of surgery of the MAR-5 group was significantly lower than that of the MAR-1 group. Preoperative administration of maropitant effectively reduces the intraoperative isoflurane requirement in a dose-dependent manner.}
    }