@article{MAKHILLJAVA20131244044,
    title = {Immunogenicity and Protective Efficacy of a Attenuated Salmonella-Vectored Vaccine Expressing Esat6 Against Tuberculosis in Mice},
    journal = {Journal of Animal and Veterinary Advances},
    volume = {12},
    number = {4},
    pages = {504-508},
    year = {2013},
    issn = {1680-5593},
    doi = {javaa.2013.504.508},
    url = {https://makhillpublications.co/view-article.php?issn=1680-5593&doi=javaa.2013.504.508},
    author = {Xudong,Shi and},
    keywords = {Mycobacterium tuberculosis,Salmonella-vectored vaccine,Esat6,efficacy,cellular immunity},
    abstract = {It is a need to develop protective vaccines against Tuberculosis (TB) that elicit full immune responses including mucosal immunity. Here an attenuated Salmonella-vectored vaccine expressing Esat6 of the <I>Mycobacterium tuberculosis</I> (Mtb) were constructed. These vaccine were assessed for their immunological efficacy on Specific Pathogen-Free (SPF) mice challenged with Mtb. The experimental data demonstrated that this SL(E6) vaccine and BCG could induce the stronger TB Ag-specific mucosal, humoral and cellular immune responses and exerted high protective efficacy in mice against virulent Mtb H37Rv challenge compared to the other vaccinated groups (mice immunized with Esat6, a DNA vaccine or BCG only). These data may represent a novel promising Salmonella vaccine candidate for the prevention of TB.}
    }