@article{MAKHILLJAVA201211153625,
    title = {Acetamiprid Residues in Male Mice and its Effect on Liver Function},
    journal = {Journal of Animal and Veterinary Advances},
    volume = {11},
    number = {15},
    pages = {2706-2710},
    year = {2012},
    issn = {1680-5593},
    doi = {javaa.2012.2706.2710},
    url = {https://makhillpublications.co/view-article.php?issn=1680-5593&doi=javaa.2012.2706.2710},
    author = {Xian-Zhong,Yi-,Jiao-Jiao,Hai-Yang,Jia- and},
    keywords = {Acetamiprid,mice,liver,residues,liver function,impairment},
    abstract = {This study was performed to identify whether acetamiprid could 
  residue in liver and kidney and its effect on liver function. Fifty adult Kunming 
  male mice weighting 25-30 g were randomly grouped and ten mice in each group 
  (five groups: control, blank, acetamiprid alone, acetamiprid+vitamin E, vitamin 
  E alone); all groups were administered for 35 days by intragastric gavage. The 
  residue in the tissues had been detected by the Liquid Chromatography coupled 
  with tandem Mass Spectrometry (LC-MS/MS) and the serum biochemistry parameters 
  were analyzed by an automatic chemistry analyzer. Acetamiprid induced a wide 
  range of nervous signs in mice; the concentration of acetamiprid in liver was 
  higher than that of kidney p<0.05. Furthermore, acetamiprid increased the 
  activity of Alanine Transaminase (ALT), Aspartate Aminotransferase (AST), Alkaline 
  Phosphatase (ALP) (p<0.05 for all) but reduced the activity of Total Protein 
  (TP) and Albumin (ALB) (p<0.05, for both). However, Vitamin E ameliorated 
  the effects of acetamiprid on these parameters, compared to the acetamiprid 
  only group (p<0.05). The results indicated that the liver was the main organ 
  of acetamiprid residues and acetamiprid could affect liver function but VE could 
  reduce acetamiprid-induced impairment.}
    }