@article{MAKHILLJAVA200985809,
    title = {Effect of Tilmicosin on Serum Cytokine Levels in the Endotoxemia},
    journal = {Journal of Animal and Veterinary Advances},
    volume = {8},
    number = {5},
    pages = {1021-1024},
    year = {2009},
    issn = {1680-5593},
    doi = {javaa.2009.1021.1024},
    url = {https://makhillpublications.co/view-article.php?issn=1680-5593&doi=javaa.2009.1021.1024},
    author = {Kamil Uney,Ayse Er,Gulcan Erbil Avci,Aziz Bulbul,Muammer Elmas and},
    keywords = {Tilmicosin,lipopolysaccharide,TNF,IL-1,IL-10},
    abstract = {The effect of tilmicosin on serum cytokine concentrations were investigated in healthy and lipopolysaccharide-treated mice. The mice were divided into 3 groups. Lipopolysaccharide (250 &#956;g,<I> Escherichia coli</I> 0111:B4, intraperitoneally) was injected into the positive control group. The other 2 groups received tilmicosin (20 mg kg<SUP>-1</SUP>, subcutaneously) concurrently without or with lipopolysaccharide. After treatment, serum samples were collected at 0, 1.5, 3, 6, 12 and 24 h. Serum tumor necrosis factor, interleukin-1 and interleukin-10 levels were determined by enzyme-linked immunosorbent assay. Lipopolysaccharide increased all cytokine levels in the healthy mice. Tilmicosin slightly induced interleukin-1 production in the healthy mice, while it had no effect on tumor necrosis factor or interleukin-10 productions. However, tilmicosin elevated (p&lt;0.05) tumor necrosis factor, interleukin-1 and interleukin-10 levels in lipopolysaccharide-treated mice. In conclusion, these data suggest that tilmicosin stimulates both proinflammatory and antiinflammatory cytokines at the dose recommended for infection.}
    }