M.N. Islam, H. Akhter, Study and Development of PIC Microcontroller-to-PC Communication via USB, International Journal of System Signal Control and Engineering Application, Volume 13,Issue 3, 2020, Pages 75-78, ISSN 1997-5422, ijssceapp.2020.75.78, (https://makhillpublications.co/view-article.php?doi=ijssceapp.2020.75.78) Abstract: In this study, researchers attempt to describe a study and development of PIC microcontroller-to-PC communication via USB. The microchip FSUSB framework utilized the PIC18F4553 with 20 MHz crystal. Port B pin RB4 has been used as bootloader and RD0 and RD1 as the status indicator. Moreover, RC5 and RC4 of PortC have been used as USB D+ and D-. Firmware tools consist of MPLAB IDE, MPLAB C18 compiler, driver, FSUSB framework V2.6 and Microsoft Visual Stadio (Visual C/C Sharp). Demonstration and Development of a complete USB2.0 communication solution has been verified by using USB Device-CDC-BASICDEMO Software on Proteus 7.7 Simulation platform. Keywords: MPLAB C18 compiler;MPLAB IDE;FSUSB framework;PIC microcontroller;USB communication;bootloader