Feyisa  Bekuma, Hagos  Ashenafi, Alemu  Tola, 
    Studies on Trypanocidal Drug Sensitivity Against <i>Trypanosoma evansi</i> in Experimentally
Infected Mice,
    Agricultural Journal,
    Volume 16,Issue 1,
    2021,
    Pages 24-28,
    ISSN 1816-9155,
    aj.2021.24.28,
    (https://makhillpublications.co/view-article.php?doi=aj.2021.24.28)
    Abstract: Trypanocidal drug sensitivity studies were
conducted to assess the efficacy of Diminazene
diaceturate (Diminasan<sup>&reg;</sup>) and Bis (aminoethylthio) 4-
melaminophenylarsine dihydrochloride (Cymelarsan<sup>&reg;</sup>)
against <i>T. evansi</i> of Colombia strain in experimentally
infected mice. Study was undertaken from November
2008 to April 2009. Diminazene diaceturate at dose range
of 3.5, 7.0, 14.0 and 28.0 mg kg<sup>&#150;1</sup> body weight failed
completely to cure <i>Trypanosoma evansi</i>. All the mice
died due to sever parasitaemia. From the present study the
minimum dose necessary to achieve 100 % cure in at least
3 mice for diminazene diaceturate is >28.0 mg kg<sup>&#150;1</sup> body
weight. However, mice treated with Cymelarsan<sup>&reg;</sup> at
higher doses of 0.5, 1.0 and 2.0 mg kg<sup>&#150;1</sup> body weight
becomes effective treatment for <i>Trypanosoma evansi</i>
Colombia strain in mice with no relapse for at least two
months. The result obtained from this study will be
important for designing similar study of <i>in vitro</i> assay to
detect drug resistance against the available isolates of
<i>T. evansi</i> from camel rearing areas of Ethiopia.
    Keywords: Diminazene diaceturate;T. evansi;mice;Colombia strain