S.A. Gharge, Varsha Jamale, Asthma Arif Hussain, B.B. Nikem, V.P. Jamale, Varsha Jamale, Compare the Efficacy and Safety Profile of Valacyclovir vs. Zinc Sulphate in Verrucae, International Journal of Tropical Medicine, Volume 11,Issue 6, 2016, Pages 276-280, ISSN 1816-3319, ijtmed.2016.276.280, (https://makhillpublications.co/view-article.php?doi=ijtmed.2016.276.280) Abstract: Warts are very serious skin diseases while the incidence of spontaneous recovery is strong, it typically takes a long time, so, certain patients do not undergo spontaneous treatment. A hospital based comparative study was conducted to compare the efficacy and safety profile of valacyclovir vs. zinc sulphate in Verruca Vulgaris. Total number of 50 patients will be selected for this study from Dermatology OPD, Krishna Hospital, Karad who will be diagnosed clinically as verruca will be included in to the study valacyclovir and zinc sulphate, both are efficacious in treatment of warts. Valacyclovir was more efficacious therapeutic option than zinc sulphate in treatment of warts. Keywords: Warts;human papillomavirus;valacyclovir;zinc sulphate;skin;cryotherapy