H.A.R. Samia  , K.H. Elmalik  , H.S. Khalid  , 
    Therapeutic Effect of <I>Aristolochia bractealata</I> Extract Against Experimental <I>Trypanosoma evansi</I> Infection,
    International Journal of Tropical Medicine,
    Volume 1,Issue 4,
    2006,
    Pages 170-172,
    ISSN 1816-3319,
    ijtmed.2006.170.172,
    (https://makhillpublications.co/view-article.php?doi=ijtmed.2006.170.172)
    Abstract: <I>Aristolochia bracteolata</I> of the family Aristolochiaceae, which was reported in the treatment of malaria and sleeping sickness, was evaluated for its <I>in vivo</I> activity against <I>Trypanosoma evansi</I> infection in rats.  Six groups of 10 rats each aged 5-7 weeks, average weight 150 grams were used.  The plant extract was administered orally at dose rates of 250 and 500 mg kg<SUP>-1</SUP> BW for both the chloroformic and methanolic extract.  The activity was compared to Cymelarsan which was given at a dose rate of 2.5 mg kg<SUP>-1</SUP> BW subcutanously.  Results showed that the plant extract gave a promising trypansocidal effect.  The chloroformic extract gave better result than that of the methanolic extract with both doses.  Its use as a new trypanocidal preparation needs further work to identify the bio-active agent(s).
    Keywords: Aristolocjia;infection rats;cholorofomic;typanocidal