Avinash  G. Bhosale, Mrs.  ShraddhaNaik, Mrs.  ArchanaGautam, S.A.  Pingale, P.B.  Patil, 
    The Efficacy of Dexmedetomidine 1 MCG/KG Single Infusion as an Adjuvant for General
Anaesthesia,
    Research Journal of Pharmacology,
    Volume 10,Issue 2-6,
    2016,
    Pages 57-61,
    ISSN 1815-9362,
    rjpharm.2016.57.61,
    (https://makhillpublications.co/view-article.php?doi=rjpharm.2016.57.61)
    Abstract: The purpose of this prospective study is to
evaluate the efficacy of dexmedetomidine in a loading
dose of 1 mcg kg<sup>&#150;1</sup> as an adjuvant to general anaesthesia.
This study was carried out in Department of
Anaesthesiology, Krishna Institute of Medical Sciences,
Karad during a period of 2014-2016. Patients were
randomly allocated into two groups of 30 patients each by
coded slips for drug combinations. Later at the time of
analysis, decoding of slips were done. All patients
received Inj. fentanyl 0.001 mg kg<sup>&#150;1</sup> and Inj. Midazolam
0.05 mg kg<sup>&#150;1</sup> intravenously. They were induced with
Inj. thiopentone sodium 5 mg kg<sup>&#150;1</sup>. Inj. vecuronium
0.12 mg kg<sup>&#150;1</sup> was used for neuromuscular blockade. After
intubation anaesthesia was maintained with sevoflurane.
Extubation was done in routine manner. Patients in
Group D took more time compared to Group N to respond
to suction catheter, to obey verbal commands and for
complete extubation. Though clinically there was not
much difference but statistically it was significant,
(p<0.05).
    Keywords: Dexmedetomidine;hemodynamic;laryngoscopy;anaesthesia;midazolam