M.H. Al-Nazawi, A.M. Homeida,
Kinetics and Tolerance of Salinomycin in Camels,
Research Journal of Pharmacology,
Volume 3,Issue 3,
2009,
Pages 48-51,
ISSN 1815-9362,
rjpharm.2009.48.51,
(https://makhillpublications.co/view-article.php?doi=rjpharm.2009.48.51)
Abstract: The pharmacokinetics of salinomycin following oral administration of 0.1 μg kg-1 body weight was studied in camels. Peak plasma concentration occurred at 40 min and decline after 2 h to fall below the limit of assay detection at 16 h post-dosing, with terminal half-life of 150 min. Animals given salinomycin at doses of 0.4-0.8 μg kg-1 orally developed neurological signs with some serobiochemical alterations. It is concluded that camels may be one of the most sensitive species to salinomycin toxicity.
Keywords: Camel;pharmacokinetics;tolerance;salinomycin;serobiochemical;peak plasma