M. Khademi, M. Kadkhodazadeh, Z. Alizadeh Tabari, Enamel Pearl as a Predisposing Factor to Localized Severe Attachment Loss: A Case Report, Research Journal of Medical Sciences, Volume 5,Issue 3, 2011, Pages 141-144, ISSN 1815-9346, rjmsci.2011.141.144, (https://makhillpublications.co/view-article.php?doi=rjmsci.2011.141.144) Abstract: Dental plaque has been implicated as the primary etiology in periodontal disease. Developmental aberrations in tooth morphology such as enamel pearls may predispose the affected area to plaque accumulation and consequently cause periodontal breakdown. Enamel pearl is defined as an ectopic globule of enamel that is firmly attached to the tooth root. The enamel pearls occurred more commonly on the roots of maxillary 2nd and 3rd molars. The most common type of enamel pearls are consisted of enamel and dentin. The aim of this study was to present a maxillary second molar with enamel pearl, associated with localized severe attachment loss and to report the pearl structural analysis. Keywords: Iran;Enamel pearl;furcation defect;periodontal destruction;pearl structure;tooth