M. Raftari, F. Azizi Jalilian, A.S. Abdulamir, R. Son, Z. Sekawy, A.B. Fatimah, Novel Approaches of E. coli O157: H7 Decontamination, Research Journal of Medical Sciences, Volume 3,Issue 4, 2009, Pages 158-162, ISSN 1815-9346, rjmsci.2009.158.162, (https://makhillpublications.co/view-article.php?doi=rjmsci.2009.158.162) Abstract: Researchers in the area of microbiological meat safety, in an attempt to reduce beef carcass contamination, try carcass-washing treatments as an effective method to control pathogenic bacteria. Spray wash treatments utilizing 3 concentrations (1, 1.5 and 2%) of acetic, lactic, propionic and formic acids were performed to evaluate their efficacy in reducing numbers of Escherichia coli O157: H7 on meat tissues at 4±1°C. The meat was decontaminated with hot water and then inoculated with E. coli O157: H7, which then was spray washed with organic acids for 15 sec separately. The population of E. coli O157: H7 significantly (p<0.05) reduced after being spray washed with all treatments. The lethality effect of all organic acids according to the concentration was 2% concentration >1.5% concentration >1% concentration. Mean log reductions of E. coli O157: H7showed that the antibacterial effect of formic acid >lactic acid >acetic acid >propionic acid. The results of this study also indicated that formic acid is a good antibacterial agent for decontaminating animals carcass surfaces. Keywords: Beef;Escherichia coli O157: H7;acetic acid;lactic acid;propionic acid and formic acid