T.O.  Ikpesu, L.I.N.  Ezemonye, 
    The Significant of Poisson Load on Tissue Alteration with Reference to Histopathological 
  Changes in Induced <I>Oreochromis niloticus</I>,
    Research Journal of Biological Sciences,
    Volume 8,Issue 5,
    2013,
    Pages 179-186,
    ISSN 1815-8846,
    rjbsci.2013.179.186,
    (https://makhillpublications.co/view-article.php?doi=rjbsci.2013.179.186)
    Abstract: The correlation between endosulfan accumulation and tissue 
  damages was examined on induced <I>Oreochromis niloticus</I>. The organization 
  for economic cooperation and development No. 407 recommended static renewal 
  bioassay was employed during the test. The test fish were exposed to sub-lethal 
  concentrations separately for a period of 7, 14, 21 and 28 days. At the end, 
  of each exposure period the liver tissues were isolated and analyzed using high 
  performance liquid chromatography for bioaccumulation study while alterations 
  observed in exposed fish were determined in the laboratory by light microscopy 
  using standard technique of haematoxylin and eosin staining. No mortalities 
  occurred in any group during the test. The severity of the histological alterations 
  observed in the liver of the treated fish, reflects the concentrations of the 
  toxicant, level of depuration and exposure durations. An indication that that 
  the regulating mechanisms of the liver has been overwhelmed resulting in the 
  structural damages. The findings showed that the body could be liberated of 
  contaminants after longer exposure period, however the effects on the body&#146;s 
  tissues remain lethal.
    Keywords: Oreochromis niloticus;liver;histopathology;endosulfan;Nigeria