Mohammad Ali Mohammad Nezhady, Naser Gharebaghi, Navid Atarod, Ehsan Jelodari, Negar Hoseinzadeh,
Evaluation of Relationship Between Iron Status and Pulmonary and Extra Pulmonary Tuberculosis: A Case-control Study,
Research Journal of Biological Sciences,
Volume 7,Issue 8,
2012,
Pages 312-315,
ISSN 1815-8846,
rjbsci.2012.312.315,
(https://makhillpublications.co/view-article.php?doi=rjbsci.2012.312.315)
Abstract: Several line of evidences have been suggested that iron is
critical for mycobacterium tuberculosis growth in macrophage and plays some
role in the susceptibility to and outcome of tuberculosis. In view of the increasing
burden of tuberculosis and lack of known risk factors for activation of tuberculosis
in some cases, the researchers decided to study this relationship using iron
indicating serum markers. In a case control study, 52 patients with pulmonary
and extra pulmonary TB and without any known risk factor for tuberculosis activation
compared with healthy subjects for serum iron, TIBC and ferritin level and transferrin
saturation rate. A total of 52 TB patients 24 with pulmonary and 28 with extrapulmonary
TB and 52 healthy individuals as control group were enrolled in the study. Mean
serum ferritin level ±SD for case and control groups were 215.95±204.37
μg dL-1 and 61.67±45.8 μg dL-1, respectively.
Mean±SD for serum iron level in case group was 62.88±30.41 μg
dL-1 and for control was 86.75±27.56. Mean±SD for TIBC
in case and control groups were 270.21±62.98 μg dL-1
and 231.71±48.57 μg dL-1, respectively. Mean±SD
for transferrin saturation in case group was 23.63±10.87% and in control
was 27.15±8.99%. The levels of iron, TIBC and ferritin showed significant
difference in 2 groups but there was no significant difference about levels
of transferrin saturation rate.
Keywords: Iron;ferritin;transferrin saturation;tuberculosis;TB;Iran