Hemmati  Ali Asghar, Arzi  Ardeshir, Tamri  Pari, 
    Anti Inflammatory Effect of Grape Seed (<I>Vitis vinifera</I>) Extract on Formalin-Induced Edema in Rat Paw,
    Research Journal of Biological Sciences,
    Volume 5,Issue 12,
    2010,
    Pages 760-763,
    ISSN 1815-8846,
    rjbsci.2010.760.763,
    (https://makhillpublications.co/view-article.php?doi=rjbsci.2010.760.763)
    Abstract: Several studies have shown that grape seed extract possess anti-inflammatory effect because of its components such as procyanidine. The purpose of this study was the investigation of the anti-inflammatory effect of grape seed extract on formalin-induced edema in rat paw. Hydroalcohlic extract of grape seed (<I>Vitis vinifera</I>) was prepared using maceration method. Albino rats weighting 180-200 g were divided in to 5 groups as intraperitoneal GSE receiving (200, 400 and 600 mg kg<SUP>-1</SUP>), positive control (indomethacin 5 mg kg<SUP>-1</SUP> p.o.) and negative control (normal saline 5 mg kg<SUP>-1</SUP> IP), 30 min following IP injection of GSE or indomethacin administration 0.1 mL of formalin (2.5% w/v) was injected in rat hind paw and the changes in rat's paw volume was assessed by plethysmometer for 3 h at intervals of 1 h. Grape seed extract (200, 400 and 600 mg kg<SUP>-1</SUP>, IP) exerted anti-inflammatory effect in a dose dependent manner. Hydroalcoholic seed extract in dose of 600 mg kg<SUP>-1</SUP> was more effective against formalin-induced paw inflammation. However, this effect was less potent than indomethacin (5 mg kg<SUP>-1</SUP>) effect as positive control.
    Keywords: Grape seed;inflammation;rat paw edema;Vitis vinifera;injection;Iran