L.  O. Ehigie, A.  S. Adekunle, M.  T Olaleye, O.  O. Odedire, B.  M. Olabinri, P.  F. Olabinri, 
    <I>In vitro</I> Evaluation of Hydroxyl and Nitric Oxide Radical Scavenging Activities of Artemether,
    Research Journal of Biological Sciences,
    Volume 5,Issue 1,
    2010,
    Pages 102-105,
    ISSN 1815-8846,
    rjbsci.2010.102.105,
    (https://makhillpublications.co/view-article.php?doi=rjbsci.2010.102.105)
    Abstract: The hydroxyl and nitric oxide radical scavenging activities and total phenolic content of artemether were investigated <I>in vitro</I>. The concentrations of artemether (200-1000 &#956;g mL<SUP>-1</SUP>) did not exhibit hydroxyl radical scavenging activity except at 200 &#956;g mL<SUP>-1</SUP> concentration. The mean values for the hydroxyl radical scavenging for the different concentration (200, 400, 600, 800 and 1000 &#956;g mL<SUP>-1</SUP>) of artemether were 47.55&plusmn;11.28, -3.49&plusmn;13.16, -30.09&plusmn;6.09, -34.74&plusmn;4.29 and -49.00&plusmn;7.75%, respectively. The total phenolic content of artemether in ethylacetate ranged from 208.00&plusmn;48.33 (SD) to 340.00&plusmn;14.14 &#956;g mL<SUP>-1</SUP>, while the total phenolic content of artemether in methanol ranged from 90.00&plusmn;6.3 (SD) to 122.00&plusmn;35.44 &#956;g mL<SUP>-1</SUP>. Total phenolic content of artemether was significantly higher in ethyl acetate than in methanol at all concentration investigated (p&lt;0.05). The total phenolic content arthemeter was influenced by the organic solvent used as a medium for preparing artemether.
    Keywords: in vitro;Artemisinins;pathophysiology;Free radical;reactive oxygen and nitrosative stress;Nigeria