M. Moezizadeh  , S. Moayedi  , 
    Anticariogenic Effect of Amorphous Calcium Phosphate Stabilized by Casein Phosphopeptid: A Review Article,
    Research Journal of Biological Sciences,
    Volume 4,Issue 1,
    2009,
    Pages 132-136,
    ISSN 1815-8846,
    rjbsci.2009.132.136,
    (https://makhillpublications.co/view-article.php?doi=rjbsci.2009.132.136)
    Abstract: The anticariogenic potential of casein phosphopeptid-amorphous calcium phosphate nanocomplexes (CPP-ACP) has been demonstrated using laboratory, animal and human <I>in situ</I> caries model. The CPP-ACP has also been shown to remineralize enamel subsurface lesions <I>in vitro</I> and <I>in situ</I> when delivered in sugar-free gum. The proposed anticariogenic mechanism for CPP-ACP is the localization of ACP at the tooth surface which buffers the free calcium and phosphate ion activities, thereby helping to maintain a state of supersaturation with respect to tooth enamel reducing demineralization and enhancing remineralization. The CPP-ACP therefore has exciting potential for use in oral care products and foods to help prevent dental caries and repair early stages of diseases, a development which will add significantly to dentists armoury of tools in preventive dentistry. This review article presents a brief on mechanism of action and role of CPP-ACP in caries prevention, remineralization of enamel lesions by CPP-ACP and use of CPP-ACP in different dental products like glass ionomer cement, tooth paste, mouth wash, tooth mousse and etc.
    Keywords: Milk;CPP;ACP;anticariogenic;enamel remineralization