Abbas Doosti  , Pooria Ghasemi-Dehkordi  , 
    Helicobacter pylori vac A Genotypes in Shahrekordian (Iran) <I>H. pylori</I>-Positive Patients,
    Research Journal of Biological Sciences,
    Volume 4,Issue 1,
    2009,
    Pages 11-15,
    ISSN 1815-8846,
    rjbsci.2009.11.15,
    (https://makhillpublications.co/view-article.php?doi=rjbsci.2009.11.15)
    Abstract: Clinical outcome of <I>Helicobacter pylori</I> infection might be associated with specific virulence-associated bacterial genotypes. The distribution of different bacterial genotypes varies geographically. The aim of this study, is based on determining any associations between the <I>Helicobacter pylori</I> <I>vac</I>A research in causing gastritis and peptic ulcer, in Shahrekord, Iran. Gastric biopsies were collected from patients that were referred to endoscopy unit of Hajar hospital Shahrekord, Iran. <I>H. pylori</I> was detected in these biopsies by culture test. Then polymorphism of <I>vac</I>A gene was genotyped by Polymerase Chain Reaction (PCR). The <I>vac</I>A genotypes were significantly different among gastritis, peptic ulcer and gastric cancer patients. Also, the <I>vac</I>A s1 allele was more frequently identified than the <I>vac</I>A s2 allele among gastrointestinal patients. Furthermore, the severest genotype of <I>vac</I>A gene in these patients was s1/m2. The results of our study illustrated that s1/m2 genotypes were associated with peptic ulceration in patients that infected by <I>H. pylori</I>.
    Keywords: Helicobacter pylori;genotype;vacA