Marianne Patricia Ntsama epse Foh Mengo  , Giampietro Corradin  , Silayuv Bongfen  , 
    The Evaluation of the Immune Response and the Effects of the Mixture of (Nt + Ct) Proteins of the Circumsporozoite (CSP) of <I>Plasmodium berghei</I> and <I>Plasmodium falciparum</I>,
    Research Journal of Biological Sciences,
    Volume 3,Issue 12,
    2008,
    Pages 1446-1451,
    ISSN 1815-8846,
    rjbsci.2008.1446.1451,
    (https://makhillpublications.co/view-article.php?doi=rjbsci.2008.1446.1451)
    Abstract: Malaria infection is initiated when an infected Anopheline mosquito injects sporozoites during a blood meal. The Circumsporozoite (CSP) protein is the major surface protein of plasmodium sporozoites and forms a dense coat on the parasite’s surface. Although, the C-terminal (Ct) portion or side of the CSP protein has been extensively studied as a malaria candidate vaccine, little is known about the N-terminal (Nt) portion and the mixture of the 2 portions (Nt + Ct) of this protein on the immune response. Our data suggest that the mixture (Nt + Ct) peptides responded well and much more better inhibition of invasion of hepatocytes was given by the use of that mixture than when Ct or Nt was used separately. The 2 peptides seem to play an important inhibitory role against the invasion of hepatocytes by sporozoites.
    Keywords: Evaluation;immune response;circumsporozoite (CSP);plasmodium berghei;plasmodium falciparum