Weiqi Zeng  , Yuequn Wang  , Wuzhou Yuan  , Yun Deng  , Yongqing Li  , Chuanbing Zhu  , Mingyao Liu  , Xiushan Wu  , 
    CTLH: A Novel Domain with A Typical "U" Shape Architecture,
    Research Journal of Biological Sciences,
    Volume 1,Issue 1,
    2006,
    Pages 12-15,
    ISSN 1815-8846,
    rjbsci.2006.12.15,
    (https://makhillpublications.co/view-article.php?doi=rjbsci.2006.12.15)
    Abstract: We described here a novel domain, CTLH, which can be found in proteins of most already-researched species  currently.  The  domain,  consisted  of  58  amino  acid  residues, is not often-conserved in sequence (but has 5 regularly-arranged leucines that are highly conserved).  However, its 3D architecture conserves greatly with a typical ´U´ shape (alpha helix+beta turn+alpha helix).  Although the function of CTLH domain remains unknown, related studies aiming at this domain suggest it participates in the regulation of certain signaling pathways like MAPK, and is involved in some living activities of cells such as protein degradation and mitosis.
    Keywords: CTLH domain;3D architecture;signaling pathways;living activities