Anatoly L.  Buchachenko, Vladimir P.  Chekhonin, Alexey P.  Orlov, Dmitry A.  Kuznetsov, 
    Zinc-Related Magnetic Isotope Effect in the Enzymatic ATP Synthesis: A Medicinal Potential of the Nuclear Spin Selectivity Phenomena,
    International Journal of Molecular Medicine and Advance Sciences,
    Volume 6,Issue 3,
    2010,
    Pages 34-37,
    ISSN 1813-176x,
    ijmmas.2010.34.37,
    (https://makhillpublications.co/view-article.php?doi=ijmmas.2010.34.37)
    Abstract: The rate of enzymatic ATP synthesis is shown to depend on the zinc isotopes. The ATP producing activities of creatine kinase and pyruvate kinase in which Zn<SUP>2+</SUP> ions have magnetic nuclei <SUP>67</SUP>Zn are found to be 2-6 times higher than that of enzymes in which Zn<SUP>2+</SUP> ions have nonmagnetic nuclei <SUP>64</SUP>Zn. The isolated rat heart muscle mitochondria exhibit a similar effect. An expression of this magnetic isotope effect in enzymatic ATP synthesis processed in the presence of Zn<SUP>2+</SUP> ions is in a favor to the ion-radical mechanism of ATP production occurred within a high zinc concentration range. Both fundamental aspect and a possible pharmacological significance of the phenomenon described are under discussion.
    Keywords: Hyper activation of the ATP synthesis;magnetic isotope effects;mitochondria function control;phenomenon;Zn+2 ion;nuclei