Lawrence M. Agius  , 
    Dynamics of Metastasis of Breast Carcinoma to Brain,
    International Journal of Molecular Medicine and Advance Sciences,
    Volume 2,Issue 3,
    2006,
    Pages 292-298,
    ISSN 1813-176x,
    ijmmas.2006.292.298,
    (https://makhillpublications.co/view-article.php?doi=ijmmas.2006.292.298)
    Abstract: A metastatic cascade appears to operate as a non-random predetermined system of selective advantage implicating initially a sieving effect by the first capillary beds in an organ of spread.  A seed-soil predilection appears to constitute a released system of promotion enhancing progression of tumor cell proliferation as a critical step in the metastatic cascade. One might redefine events in terms of promotion of pathways influencing subsequent acquisition of attributes.  Permeation and embolic spread via vessels would constitute a realized idealization of events primarily characterized in terms of ongoing changes in phenotype of tumor cells both as genetically unstable cells and as increasingly self-progressive pathways of strictly sequential type.
    Keywords: Dynamics;breast carcinoma;proliferation