Belinda Edwin , Gwendolyne Tanil Bulan , Lesley Maurice , Salmah Ismail , Jacintha Sugnaseelan , Cheah Yok Kqueen , Son Radu , Isolation, Antibiotic Resistance and Plasmid Profiling of Vibrio alginolyticus from Cockles (Anadara granosa), Journal of Food Technology, Volume 2,Issue 1, 2004, Pages 50-55, ISSN 1684-8462, jftech.2004.50.55, (https://makhillpublications.co/view-article.php?doi=jftech.2004.50.55) Abstract: A total of forty-three Vibrio alginolyticus strains isolated from cockles collected from wet markets were studied for their resistance to antibiotics and plasmid profiles. All isolates were resistant to one or more of the fifteen antibiotics tested. Twenty different antimicrobial resistance patterns were obtained, suggesting that they do not share a common resistance pattern. The multiple antibiotics resistance indexes indicate that most of the V. alginolyticus isolates originated from high-risk sources. The isolates showed high-resistance towards vancomycin (100%), penicillin G (97.7%), bacitracin (95.4%), cephalothin (86.1%), carbenicillin (83.7%), ampicillin (79.1%), erythromycin (79.1%) and tetracycline (55.8%), and low-resistance towards streptomycin (27.9%), chloramphenicol (11.6%), moxalactam/latomoxef (4.7%) and nalidixic acid (2.3%). However, all were susceptible to gentamicin, kanamycin and norfloxacin. Twenty-seven (62.8%) isolates were plasmidless, while sixteen (37.2%) harboured either one or two low molecular weight plasmid(s) ranging between 2.1 and 3.74 MDa. The antibiotic resistance test was more discriminating compared to plasmid profiling and is well suited to characterised the V. alginolyticus strains. Keywords: