Sachiko  Arai, Seigo  Itoh, Maiko  Watabnabe, Fujiko  Sunaga, Sugita-  Konishi, 
    A Comparison of the Emetic Toxicity of Deoxynivalenol and
Acetyl Deoxynivalenol in House Musk Shrews (<I>Suncus murinus</I>),
    Journal of Animal and Veterinary Advances,
    Volume 12,Issue 6,
    2013,
    Pages 718-720,
    ISSN 1680-5593,
    javaa.2013.718.720,
    (https://makhillpublications.co/view-article.php?doi=javaa.2013.718.720)
    Abstract: The emetic toxicities of deoxynivalenol and its acetyl derivatives 
  were examined using house musk shrews (<I>Suncus murinus</I>). Emesis was observed 
  after the oral administration of these toxins at doses ranging from 0-40 mg 
  kg<SUP>-1</SUP> B.W. The Effective Dose (ED) causing emesis was calculated using 
  the Probit Method. The ED 50 of deoxynivalenol, 3-acetylnivalenol and 15-acetylnivalenol 
  was 3.85, 0.87 and 8.85 mg kg<SUP>-1</SUP> B.W., respectively. The results show 
  that the emetic toxicity of 3-acetylnivalenol is 10 times higher than that of 
  deoxynivalenol or 15-acetyl deoxynivalenol. Even though, acetyl deoxynivalenol 
  has been determined to exhibit equivalent toxicity to deoxynivalenol by the 
  FAO/WHO Joint Food Additives Committee, the different responses of acute emetic 
  toxicity should, therefore be taken into account.
    Keywords: Emesis;deoxynivalenol;3-acecylnivalenol;15-acecylnivalenol;Probit Method