Qing-Hua  Chen, Xiang-Qing  Zhu, Li Lei  , Qiong Wu  , Qiang Wang  , Cui-Zhu Chen  , Xue-Min Cai  , Rong-Qing Pang  , Xing-Hua Pan  , 
    Induced Multipotent Stem Cells Combining with HAP/TCP/CS Composite Scaffold Repairs Bone Defect,
    Journal of Animal and Veterinary Advances,
    Volume 12,Issue 5,
    2013,
    Pages 573-580,
    ISSN 1680-5593,
    javaa.2013.573.580,
    (https://makhillpublications.co/view-article.php?doi=javaa.2013.573.580)
    Abstract: The treatment of bone defect is the multi-disciplinary clinical 
  problem. Although, several types of bone graft materials are used for clinical 
  study, numerous hurdles such as infection and immune rejection need to be resolved 
  in essence. Various types of stem cells combining with biological material for 
  repairing bone defect is a promising way. However, the poor resource of stem 
  cells has restricted their clinical application. In earlier research, researchers 
  had reported that transient <I>in vitro</I> epigenetic reprogramming of mouse 
  skin fibroblasts into multipotent stem cells. In this study, researchers used 
  the similar method to reprogram dog skin fibroblasts into multipotent stem cells. 
  Further, reprogrammed cells were re-differentiated into osteogenesis-like cells 
  <I>in vitro</I>. Especially, iMS cells combining with Hydroxyapatite/&#946;-Tricalcium 
  Phosphate/Chitosan (HAP/&#946;-TCP/CS) Composite Scaffold could repair bone 
  defect in dog. The results indicated that the iMS could be used as seed cell 
  for repairing bone defect in clinical application.
    Keywords: Induced multipotent stem cells;scaffold;cell hybrid material;bone defect;repairin