Won-Il  Kim, Nadeem  Shabir, Byung-Dae  Yoon, Amina  Khatun, Bum-Seok  Kim, Ji-Hoon  Shin, Keug-Hyun  Ahn, 
    Effects of Dietary Addition of β-Glucan on Pigs Infected with Salmonella Typhimuriu,
    Journal of Animal and Veterinary Advances,
    Volume 12,Issue 23,
    2013,
    Pages 1657-1664,
    ISSN 1680-5593,
    javaa.2013.1657.1664,
    (https://makhillpublications.co/view-article.php?doi=javaa.2013.1657.1664)
    Abstract: Although, the antimicrobial effects of &#946;-Glucan (BG) have been described previously, the use of &#946;-glucan in food animal production has been unrealistic due to high production costs. Recently, pure &#946;-glucan could be efficiently produced by cultivating mutant <I>Aureobasidium pullans</I> which contains a disrupted <I>pul</I> gene and the new method can simplify purification process and reduce mass production costs. Thus, the effect of the &#946;-glucan purified from mutant <I>A. pullans</I> on salmonella infection in weaned pigs was evaluated in the study. Twenty, 4 weeks old pigs were randomly assigned to the following 4 groups: BG or BG-X group was provided with commercial feeds containing &#946;-glucan (10 mg kg<SUP>-1</SUP>) or containing both &#946;-glucan (10 mg kg<SUP>-1</SUP>) and Genkwadaphnin (10 mg kg<SUP>-1</SUP>), respectively; Normal Feed (NF) and Negative control (Neg.) groups were only provided with commercial feeds only. All the groups were provided with their specific diets for 2 weeks, challenged with Salmonella Typhimurium at 10<SUP>8</SUP> Colony Forming Units (CFU)/mL except for the Neg. group and sacrificed for pathological evaluation at 4 weeks after the challenge. As compared with the NF group, BG and BG-X groups showed significantly lower diarrhea incidence and salmonella shedding in feces and gained more weight after salmonella infection. Gross lesions were less severe in BG and BG-X groups but the differences reached no statistical significance. In conclusion this study demonstrated that the overall performance of weaned pigs fed &#946;-glucan derived from <I>A. pullan</I> was enhanced upon challenge with salmonella by increasing weight gains and reducing both the incidence of diarrhea and fecal shedding of salmonella.
    Keywords: &#946;-glucan;genkwadaphnin;Aureobasidium pullan;Salmonella Typhimurium;weaned pigs