Sun  Boxing, Su  Jiazi, Zhang  Jinyu, Zhang  Mingjun, Meng  Jilun, Guo  Jiang, Li  Zezhong, Guan  Yuntao, Li  Yanbing, Zhao  Zhihui, 
    Expression of Immunoglobulin Genes Differs Between Chickens and Ducks Following H5N1 Avian Influenza Virus Infection,
    Journal of Animal and Veterinary Advances,
    Volume 12,Issue 15,
    2013,
    Pages 1289-1295,
    ISSN 1680-5593,
    javaa.2013.1289.1295,
    (https://makhillpublications.co/view-article.php?doi=javaa.2013.1289.1295)
    Abstract: Different species have different susceptibilities to Avian 
  Influenza Virus (AIV). In the present study, the expression profiles of Immunoglobulins 
  (Igs) in different tissues of Specific Pathogen-Free (SPF) chickens and ducks 
  infected with AIV were examined by quantitative PCR (qPCR) and compared with 
  those of normal controls. The results showed that the copy numbers of IgA in 
  AIV-infected chickens and ducks sharply increased in the spleen, thymus, bursa 
  of Fabricius, lung and tracheal mucosa (p<0.05). Significant changes were 
  also observed in the expression of IgM and IgY in the spleen, thymus and bursa 
  of fabricius in AIV-infected chickens and ducks (p<0.05). Ducks had higher 
  expression of all three Ig classes than chickens after AIV infection. Additionally, 
  ducks expressed a unique form of IgY (ΔFc) that exhibited significant changes 
  in the spleen, thymus, bursa of Fabricius and lungs following AIV infection 
  (p<0.05). The unique form was expressed at higher levels than full-length 
  IgY. The expression patterns of these Igs may explain why chickens and ducks 
  have different disease signs following AIV infection. The expression of immunoglobulin 
  could affect the susceptibility of chickens and ducks to the H5N1 influenza 
  virus.
    Keywords: Avian influenza virus;chicken;duck;immunoglobulin;susceptibility;AIV infection