Guo  Guangzhou, Zhang  Dongxiao, Yang  Fan, Wang  Bing, Liu  Tao, Xue  Caifang, Zhang  Renli, 
    Blood Selenium of Low-Level Associated with Development of Hand-Foot-Mouth-Disease,
    Journal of Animal and Veterinary Advances,
    Volume 11,Issue 3,
    2012,
    Pages 381-385,
    ISSN 1680-5593,
    javaa.2012.381.385,
    (https://makhillpublications.co/view-article.php?doi=javaa.2012.381.385)
    Abstract: In this study, 207 healthy children groups from 0-6 years old was subjected to 
analysis of subclinical infection of EV71, 25 subclinical infection blood selenium 
level of 45 healthy people and 41 HFMD patients were compared. Positive rate of 
subclinical infection of anti-EV71 IgG antibody was 10.8% (17/157) and 26% (13/50), 
respectively in two healthy children groups, the 0-3 and 4-6 years old groups 
that of IgM anti-body were 15.2% (24/157) and 8.0% (4/50), respectively. There 
was highly significant difference (p<0.01) in the positive rate of anti-EV71 
IgG and IgM antibodies in both age groups. The positive rate of EV71 nucleic acid 
in 28 patients with positive anti-EV71 IgM antibody was 89.2% (25/28). The blood 
selenium level of 41 HFMD patients, 25 subclinical infection and 45 healthy people 
were (&#956;g g<SUP>&#150;1</SUP>) 0.081&plusmn;0.01, 0.132&plusmn;0.031 and 0.137&plusmn;0.024, 
respectively. There was highly significant difference (p&lt;0.01) in blood selenium 
level between the HFMD group and two other groups compared by Chi-square (&#967;<SUP>2</SUP>) 
test. A large number of children under the age of 6 years had EV71 subclinical 
infection. The patients with EV71 infection and low blood selenium were susceptible 
to HFMD.
    Keywords: HFMD;latent infection;blood selenium;antibody;children;China