Zirong  Xu, Haizhi  Quan, 
    Hypotheses: A New Way Against Cancer Metastasis, Chitooligosaccharides as Mucosal Adjuvant for Therapeutic Vaccination Targeting Heparanase,
    Journal of Animal and Veterinary Advances,
    Volume 11,Issue 15,
    2012,
    Pages 2788-2791,
    ISSN 1680-5593,
    javaa.2012.2788.2791,
    (https://makhillpublications.co/view-article.php?doi=javaa.2012.2788.2791)
    Abstract: Heparanase is a tumor metastasis associated antigen so cancer vaccine targeting heparanase is an effective way to treat tumor metastasis. However, cancer vaccine needs adjuvant because of low immunostimulatory. Chitooligosaccharides (COS) has been proved to be an successful cancer vaccine adjuvant due to its propertied. COS will be a well adjuvant for cancer vaccine targeting heparanase.
    Keywords: Heparanase;chitooligosaccharide;tumor metastasis;adjuvant;cancer vaccine