Yulong  Yin, Xiangshan  Tang, Andrew  A. Fatufe, Zhiru  Tang, Shengping  Wang, Zhiqiang  Liu, Xinwu  , Tie-Jun  Li, 
    Dietary Supplementation with Recombinant Lactoferrampin-Lactoferricin Improves Growth 
  Performance and Affects Serum Parameters in Piglets,
    Journal of Animal and Veterinary Advances,
    Volume 11,Issue 14,
    2012,
    Pages 2548-2555,
    ISSN 1680-5593,
    javaa.2012.2548.2555,
    (https://makhillpublications.co/view-article.php?doi=javaa.2012.2548.2555)
    Abstract: Up to thirty piglets with an average live body weight of 5.9&plusmn;0.5 kg were challenged using enterotoxigenic<I> Escherichia coli</I> and randomly assigned to three treatment groups fed a corn-soybean meal-based diet containing either no addition (control group), 0.1 g kg<SUP>-1</SUP> of lactoferrampin-lactoferricin (lactoferrampin-lactoferricin group) or 0.1 g kg<SUP>-1</SUP> of chlortetracycline (chlortetracycline group) for 21 days. Compared with the control group, dietary supplementation with lactoferrampin-lactoferricin or chlortetracycline increased the body weight and daily weight gain and decreased the feed to gain ratio, diarrhea rate and serum IgM and IgG levels (p&lt;0.05). The serum levels of IL-1&#946;, IL-6, TNF-&#945;, diamine oxidase and endothelin-1 were not significantly different among all treatment groups (p&gt;0.05). Compared with the control group, dietary supplementation with lactoferrampin-lactoferricin changed the serum concentrations of 10 amino acids (p&lt;0.05); dietary supplementation with chlortetracycline only changed the serum histidine concentration (p&lt;0.05). These results indicate that lactoferrampin-lactoferricin and chlortetracycline have similar effects on piglets weaned at 21 days of age which is expected to have practical applications in the livestock industry.
    Keywords: Antimicrobial peptide;bovine lactoferrampin-lactoferricin;growth performance;piglet;China