M.  Fang, J.B.  Zhang, X.X.  Dong, Y.  Bai, Y.Z.  Yang, 
    Expression Analysis of <I>HIF-1&#945;</I> and <I>HIF-2&#945;</I> Genes in Tibetan Chicken under Normoxia and Hypoxia,
    Journal of Animal and Veterinary Advances,
    Volume 10,Issue 16,
    2011,
    Pages 2172-2175,
    ISSN 1680-5593,
    javaa.2011.2172.2175,
    (https://makhillpublications.co/view-article.php?doi=javaa.2011.2172.2175)
    Abstract: Tibetan chicken is one of those chicken breeds that could adapt to high altitude and low O<SUB>2</SUB> tension environment; it owes an integrative genetic mechanism for hypoxia adaptability compared to lowland chicken breeds. HIF-1&#945; and HIF-2&#945; are the central factors playing important roles in maintaining organisms&#146;s oxygen homeostasis. In this study, the expression of <I>HIF-1&#945;</I> and <I>HIF-2&#945;</I> genes were investigated by Real Time-PCR in Tibetan chicken and Dwarf chicken embryo brain tissue under normoxia (21% oxygen concentration) and hypoxia (13% oxygen concentration). The results showed that Tibetan chicken always had lower mortality than Dwarf chicken during the incubation. We also detected higher HIF-&#945;s expression at the late of incubation (18th day) compared with that at 12th day in all tested samples; we further obtained the expression pattern of <I>HIF-&#945;s</I> genes in dead embryos was opposite to that in live embryos.
    Keywords: hypoxia;normoxia;HIF-2a;HIF-1a;Tibetan chicken;adaptability