Like  Wang, Zhihua  Cai, Deyi  Liu, Shenghe  Li, Xunsheng  Pang, Yuxin  Cheng, 
    Polymorphism Identification and Association Analysis of <I>IRF3</I> Gene in Pig,
    Journal of Animal and Veterinary Advances,
    Volume 10,Issue 14,
    2011,
    Pages 1841-1844,
    ISSN 1680-5593,
    javaa.2011.1841.1844,
    (https://makhillpublications.co/view-article.php?doi=javaa.2011.1841.1844)
    Abstract: In this study, <I>IRF3</I> gene was chosen as a candidate gene for evaluating its effect on porcine immune traits. A SNP (HQ026024: g.4252T&gt;C) in exon7 of <I>IRF3</I> gene was demonstrated by PCR-SSCP analysis and sequencing. Immune traits including IFN-&#947; and IL10 concentrations in serum were measured when the pigs are at 20th day of age. The further association analysis of SNP genotypes with immune traits were also conducted in 3 pig breeds including Large white, Landraces and Chinese indigenous breed Dingyuan black pig. The results indicated that the SNP of <I>IRF3</I> gene had highly significant effects on level of IFN-&#947; and IL10 (day 20) in serum (p = 0.0344; p = 0.0121) and ratio of IFN-&#947; to IL10 (day 20) in serum (p = 0.0315). The results suggested that the <I>IRF3</I> gene could be regarded as a molecular marker gene for genetic selection of these immune traits in the pig breeding program.
    Keywords: China;Pig;association analysis;PCR-SSCP;polymorphism;IRF3 gene