Yu  Shi-Gang, Xin  Ya-Ping, Xin  Jing-Jing, Huang  Yong-Zhen, Yu  Hui, Wang  Mou, Yao  Xin-Kui, Tian  Ke-Chuan, Huang  Xi-Xia, Fang  Yi, Liu  Wu-Jun, Fang  Guang-Xin, Chen  Hong, 
    The Polymorphism of a Mutation of IGF-1 Gene on Two Goat Breeds in China,
    Journal of Animal and Veterinary Advances,
    Volume 9,Issue 4,
    2010,
    Pages 790-794,
    ISSN 1680-5593,
    javaa.2010.790.794,
    (https://makhillpublications.co/view-article.php?doi=javaa.2010.790.794)
    Abstract: Searching for effects of candidate gene polymorphisms on cashmere production traits is an important goal for goat industry. Genetic variations in IGF-1 may alter protein function. This study investigated the association between polymorphisms in insulin-like growth factor-1 (IGF-1) and cashmere traits data with two Xinjiang local goat breeds. The results showed IGF-1-P1 locus has polymorphisms. The polymorphism locus of IGF-1-P1 by PCR-RFLP and DNA sequencing methods in 530 individuals from two Xinjiang local goat breeds in China. The frequencies of genotype AA in two goat breeds (Xinjiang goat, Nanjiang cashmere goat) were 0.487 and 0.277. Genotype BB was 0.274 and 0.486. Genotype AB was 0.239 and 0.236. The polymorphisms of the IGF-1 gene were associated with cashmere yield, fiber diameter, body weight in cashmere goat. However, concern on cashmere production traits among three genotypes were shown not significantly (p>0.05).
    Keywords: cashmere traits;cashmere goat;IGF-1 gene;PCR-RFLP;genotypes;China