Mehmet  Cay, Mustafa  Ulas, 
    Effects of Estrogen Replacement Therapy with Vitamin E on Oxidative Stress in Hepatic and Pancreatic Tissues of Ovariectomized Diabetic Rats,
    Journal of Animal and Veterinary Advances,
    Volume 9,Issue 23,
    2010,
    Pages 2955-2962,
    ISSN 1680-5593,
    javaa.2010.2955.2962,
    (https://makhillpublications.co/view-article.php?doi=javaa.2010.2955.2962)
    Abstract: We investigate the effects of 17&#946;-estradiol (E<SUB>2</SUB>) and vitamin E on oxidative stress of hepatic and pancreatic tissues in Ovariectomized (OVX) diabetic rats. Fortynine rats were equally divided into seven groups: Control; OVX; OVX+E<SUB>2</SUB>; OVX+E<SUB>2</SUB>+Vitamin E; OVX+Diabetic; OVX+Diabetic+E<SUB>2</SUB> and OVX+Diabetic+E<SUB>2</SUB>+Vitamin E. The Glutathione Peroxidase (GSH-Px), Superoxide Dismutase (SOD), Catalase (CAT), Glutathione (GSH) and vitamin A and &#946;-carotene in liver and pancreas were reduced when compared with control but Malondialdehide (MDA) was raised. E<SUB>2 </SUB>and E<SUB>2</SUB>+vitamin E supplementations to OVX rats increased GSH-Px, SOD, CAT, GSH, vitamin A and &#946;-carotene in liver and pancreas but decreased MDA. MDA in liver and pancreas, Aspartate amino Transferase (AST), Alanine amino Transferase (ALT), Lactate Dehydrogenase (LDH), &#946;-glutamyl Transferase (GGT) and Alkaline Phosphatase (ALP) in the serum of diabetic OVX rats were raised when compared with OVX but the activities antioxidant enzyme, GSH, vitamin A and &#946;-carotene in liver and pancreas were lowered. The GSH-Px, SOD, CAT, GSH, vitamin A and &#946;-carotene in liver and pancreas increased, although MDA in liver and pancreas and AST, ALT, LDH, GGT and ALP in serum decreased in diabetic OVX after E<SUB>2</SUB> and E<SUB>2</SUB>+vitamin E supplementation.
    Keywords: Ovariectomy;estrogen;vitamin E;MDA;AST;ALT