H.E.  Mohamed, A.  Alhaidary, A.C.  Beynen, 
    Nephrocalcinosis and Urinary Mineral Concentrations in Rats Fed Diets Containing Various Concentrations of Magnesium,
    Journal of Animal and Veterinary Advances,
    Volume 9,Issue 18,
    2010,
    Pages 2405-2408,
    ISSN 1680-5593,
    javaa.2010.2405.2408,
    (https://makhillpublications.co/view-article.php?doi=javaa.2010.2405.2408)
    Abstract: High magnesium intakes are known to inhibit the development of nephrocalcinosis in female rats but there was no information on the dose-response relationship and the underlying mechanism. In an attempt to collect the lacking information, female rats were fed diets containing 0.02-0.24% magnesium as the only variable. Increasing dietary magnesium concentrations were found to reduce nephrocalcinosis in a dose-dependent fashion. The lowest dietary magnesium level produced a kidney calcium concentration of 10.6% in the dry matter whereas the highest magnesium intake reduced kidney calcium to 0.2%. Increasing dietary magnesium concentrations produced increasing urinary magnesium concentrations in combination with decreasing phosphorus concentrations. It is suggested that the magnesium-induced inhibition of nephrocalcinosis is caused by a decrease in urinary phosphorus and increase in urinary magnesium.
    Keywords: Rats;nephrocalcinosis;diet;urine;magnesium;phosphorus;concentrations