Nihal Y.  Gul, Suna  Gedikoglu, Cuneyt  Ozakin, Hulya  Bilgin, Ayse  Topal, 
    Growth of <I>Staphylococcus aureus</I>, <I>Candida albicans</I>, <I>Escherichia coli</I> and <I>Pseudomonas aeruginosa</I> in Propofol, Thiopental and a 1:1 Propofol-Thiopental Mixture,
    Journal of Animal and Veterinary Advances,
    Volume 9,Issue 10,
    2010,
    Pages 1432-1435,
    ISSN 1680-5593,
    javaa.2010.1432.1435,
    (https://makhillpublications.co/view-article.php?doi=javaa.2010.1432.1435)
    Abstract: Extrinsic contamination of propofol is thought to be a source of postoperative sepsis. Researchers studied growth of <I>Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli</I> and <I>Candida albicans</I> in propofol, thiopental and in a 1:1 propofol-thiopental mixture. All microorganisms were taken from standard stock cultures. Half of the samples were incubated at 20&deg;C and the rest were stored at 4&deg;C for 120 h. Growth of microorganisms in each solution was compared by counting the number of the Colony-Forming Units (CFUs) at 0, 3, 6, 24, 72 and 120 h. Propofol supported the growth of all four microorganims at both temperatures. In contrast, thiopental and the 1:1 propofol-thiopental mixture exhibited markedly bactericidal properties on <I>E. coli, C. albicans</I> and<I> P. aeruginosa </I>and bacteriostatic effect on <I>S. aureus</I>.
    Keywords: thiopental; mixture;propofol;Intravenous anesthetics;bacteria;growth rate