Gorkem Kismali  , Elcin Ozgur  , Serkan Sayiner  , Burcu Alpaslan  , Goknur Guler  , Nesrin Seyhan  , Tevhide Sel  , 
    The Effects of Epigallocatechin Gallate and N-Acetylcysteine on Mobile Phone-Induced Oxidative Stress in Guinea Pigs,
    Journal of Animal and Veterinary Advances,
    Volume 8,Issue 5,
    2009,
    Pages 959-961,
    ISSN 1680-5593,
    javaa.2009.959.961,
    (https://makhillpublications.co/view-article.php?doi=javaa.2009.959.961)
    Abstract: It has been reported that mobile phones induce free radical formation. Epigallocatechin Gallate (EGCG) and N-Acetylcysteine (NAC) were recently found to be potent antioxidants. The present study was carried out to determine the protective effects of antioxidants namely EGCG and NAC against the mobile phone-induced oxidative stress. Three-month-old male Guinea pigs were randomized into 6 groups; sham group, not exposed to mobile phone, NAC group (300 mg kg<SUP>-1</SUP> ip, 7 days), 10 min mobile phone-exposed group with NAC, 10 min mobile phone-exposed group, EGCG group (25 mg kg<SUP>-1</SUP> ip, 7 days) and 10 min mobile phone-exposed group with EGCG. During the exposure external E fields were measured by NARDA EMR 300 and type 8.3 probe. Guinea pigs were exposed to RFR averaged as 11.2&plusmn;0.5 V m<SUP>-1</SUP> for 10 min/day/7days. Malondialdehyde (MDA, an index of lipid peroxidation) were analysed as markers of oxidative stress. Plasma MDA levels increased in mobile phone exposed guinea pigs while EGCG causes a significant reduction of MDA levels, whereas NAC caused a significant increase in MDA levels. Also, MDA levels in mobile phone exposure group significantly increased with respect to sham exposure group. A number of studies have identified antioxidant species which show antioxidant effect in low-dose and pro-oxidant behaviour in high-dose. The increase of the lipid peroxidation at the treatment dose of NAC in guinea pigs may possibly be due to pro-oxidant behaviour. Besides, this study expressed that mobile phone exposure affect the level of lipid peroxidation of plasma.
    Keywords: Epigallocatechin gallate;n-acetylcysteine;oxidative stres;mobile phone;guinea pigs;MDA