Zhang  Li-Fan, Miao  Xiu-Ting, Hua  Xu-Chuan, Jiang  Xiao-Ling, Lu  Yuan-Peng, Xu  Ning-Ying, 
    Polymorphism in 5' Regulatory Region of the Porcine Fat Mass and Obesity Associated (FTO) Gene is Associated with Intramuscular Fat Content in a Jinhua x Pietrain F<sub>2</sub> Reference Population,
    Journal of Animal and Veterinary Advances,
    Volume 8,Issue 11,
    2009,
    Pages 2329-2334,
    ISSN 1680-5593,
    javaa.2009.2329.2334,
    (https://makhillpublications.co/view-article.php?doi=javaa.2009.2329.2334)
    Abstract: As a newly described candidate gene in obesity, FTO gene showed a strong and highly significant association with the obesity-related traits in various human populations. It has been suggested that FTO gene play a key role in the regulation of energy balance and feed intake. Here we sequenced the -2.0 kb of the 5' flanking region of the porcine FTO gene, 7 SNPs were detected in this region and genotyped on the Jinhua x Pietrain F<sub>2</sub> reference population. Using a gene-wide haplotype-tagging approach, three tag SNPs were examined. The SNPs of g -1191 A&gt;G had significant associations with Intramuscular Fat (IMF) content (p&lt;0.05), but not with the Average Backfat Thickness (ABF), Leaf Fat weight (LF) or Average Daily Gain (ADG). Additionally, allele frequencies of the g -1191A&gt;G mutation were studied in 6 pig breeds and the G allele was mainly occurred in Chinese native pig breeds. These results provided the solid evidence that FTO gene was associated with the intramuscular fat deposition in pigs.
    Keywords: Porcine;regulatory polymorphism;fat mass and obesity associated gene;fat deposition