Samia A.A. Hassan  , Sana A.I. Shaddad  , A.K. Muddathir  , I.B. El-Tayeb  , A.O.M. Nour  , M.H. Al-Nazawi  , A.M. Homeida  , 
    Pharmacokinetics of Long-Acting Oxytetracycline Formulation Following Intramuscular Administration in Desert Sheep,
    Journal of Animal and Veterinary Advances,
    Volume 7,Issue 4,
    2008,
    Pages 433-436,
    ISSN 1680-5593,
    javaa.2008.433.436,
    (https://makhillpublications.co/view-article.php?doi=javaa.2008.433.436)
    Abstract: The pharmacokinetics of long-acting Oxytetracycline (OTC) formulation (Alamycin-LA) was studied after intramuscular (IM) route at a dose of 1 mg kg <SUP>1</SUP> body weight to fifteen healthy desert sheep. The mean C<SUB>max</SUB> values of 74.8±13.22 µg mL <SUP>1</SUP> was after 0.9±0.13 h, the mean distribution phase was 2.0±0.4 h and the apparent elimination half-life was 126±23 h. The volume of distribution (V<SUB>d</SUB>) was found to be 67.933±4.88 L. The area under the curve (AUC<SUP>0</SUP><SUB>240</SUB>) and the area under concentration-time curve (AUMC) were 2530.26±203.3, 242522.2±48504.5 µg/ml/h<SUP>2</SUP>, respectively. The total body clearance (cl<SUB> </SUB>) was 373.63±18.9 mL h <SUP>1</SUP> while the mean resident time (MRT) was 90.61±13.8 h.
    Keywords: Pharmacokinetic;intramuscular;long-acting oxytetracycline;sheep