Salmah Ismail  , Son Radu  , Khalifah Sidek  , Mohd Azhar Arifffin  , Mohammad Nazmul Hasan Maziz  , Irwan Hamzah  , Mahmood Ameen Abdulla  , 
    Effect of Dexamethasone Treatment on the Hematological and Histological Parameters of Mice Following Experimental Bacterial Infection,
    Journal of Animal and Veterinary Advances,
    Volume 2,Issue 4,
    2003,
    Pages 231-236,
    ISSN 1680-5593,
    javaa.2003.231.236,
    (https://makhillpublications.co/view-article.php?doi=javaa.2003.231.236)
    Abstract: There are four groups of balb/c mice with each of it consists of 6 animals. Group 1, 2 and 3 were injected with dexamethasone daily for three days and experimentally infected with Pasteurella multocida, Escherichia coli harboring a recombinant plasmid ABA392 and Staphylococcus aureus respectively. Whereas, group four serve as control. At 24, 48 and 72 hours post-infection a marked increase in total leucocytes counts while differential leucocytes count revealed a marked increase in neutrophils and decrease in lymphocytes and monocytes in all dexamethasone-treated animals and was more predominant in group 1 and 2 post infection in all animals. At 72 hours post-infection, the histological examination reveals haemorrhagic (hemorrhagic septicaemia) features of lungs in dexamethasone-treated mice and infected with P. multocida and the recombinant plasmid ABA392 but not with the dexamethasone-treated and infected with S. aureus indicate that recombinant plasmid ABA392 may harbor a sequence that may code for virulent factor of Pasteurella multocida.
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