Nizamani Z , L. A. Siddiqui , R.Rind , M. Khaskheli , A. W. Nizamani , Studies of Escherichia Coli from Layers and Broilers, Journal of Animal and Veterinary Advances, Volume 2,Issue 4, 2003, Pages 221-224, ISSN 1680-5593, javaa.2003.221.224, (https://makhillpublications.co/view-article.php?doi=javaa.2003.221.224) Abstract: A total of 150 poultry carcasses, 75 broilers, and 75 layers were collected and examined for the presence of gross necrotic lesions on various organs. Of the 75 broilers, 3 age groups were investigated. Group A with age of 1-4 weeks, group B and C were of 4 - 8 and 8 - 12 weeks of age respectively. From each group 25 poultry carcasses were investigated. The higher incidence of E. coli infection was recorded in group A followed by groups B and C respectively. On the other hand, 75 carcasses of layers were studied through postmortem examination. Of the 25 carcasses with age of 1 - 8 weeks from group A, where as the birds of 8 - 16 and 16 - 24 weeks of age from group B and C respectively. During this study, a higher infection rate recorded in birds of 1 - 8 weeks compared to letter two groups. Five different organs, livers, intestines, lungs, hearts, and ovaries of broilers each of 25 in number from 3 age groups collected and examined. The highest positive percentage for E. coli was recorded in intestine (80%) followed by liver (68%), heart (64%), lungs (56%) and ovary (32%) in age group of 1 - 4 weeks as compared to other two groups. From layers same type and number of organs were examined. The highest infection rate was recorded in the intestine (84%) followed by liver (72%), heart (68%), lungs (60%) and ovary (36%) in age group of 1 - 8 weeks as compared to group B and C. Keywords: